grub error 22??? help

[bubba]

I have installed kubuntu with a cd created from iso downloaded, on a pen 
drive.
When i made a partition i have partitioned the pen drive.
When i restarted the computer whitout the pen drive inside the system 
did not start GRUB ERROR 22.
The computer start only with the pen drive inside.
How can i solve this problem?
If i make a new partition of my hard disk in which i install Kubuntu the 
computer will works whitout any problem?
Thanks all for helping me, and sorry for my english.