Something is wrong with my PC?

[Jim Kvarnberg]

I installed, uninstalled and re-installed Ubuntu 9.04, Ubuntu 9.10, 
Ubuntu 10.04 and Windows XP Pro again and again because the mouse won't 
catch when being clicked.  When the OS was freshly booted up, it worked 
ok and then a moment later, it quitted working.  Then I tried Ubuntu 
8.04 and the mouse worked!  Does this ring a bell?
My PC is home assembled with ASUS M2N-MX SE PLUS motherboard, AMD Athlon 
64 X2 CPU. 4 gb ram and 320 gb SATA hard drive.  Me an old dog 
struggling to learn a new trick.  I love Ubuntu, but I think I am losing 
my interest in it due to too much problems even Windows XP.  That 
frustrated me.  Any explanation or tips for solution to the mouse 
problem will be greatly appreciated. Which motherboard is best for 
running the Linux based OS?   Thank you.  Jim