Problems upgrading 21.10 to 22.04?

[MR ZenWiz]

I hear good and bad about this move. I want to do it, but I don't want
to cripple anything.

I usually stick to the LTS releases, but my desktop has a Ryzen 9 CPU
which doesn't run anything older than 21.10.

Any sage advice?  What should I look out for?

I have 22.04 in a VM, but that doesn't say a lot about what might
happen on my host.

Thanks!

Mark